A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Glutathione and Toxicology and Liver Disease Glutathione Reporter Mechanisms of drug induced liver injury Semantic Scholar Glutathione in liver diseases and hepatotoxicity. Semantic Scholar Cystathionine Lyase Protects Against Choline Deficient High Fat Diet Induced Metabolic Dysfunction Associated Steatotic Liver Disease Through the CysteineGlutathione Axis in Mice Min Ji Kim, You Ri Park, Gibong Jang, Yong Kwon Han, Isao Ishii,