Oral Melanotic Macule MEDizzy Clinical Challenge: Dark Lesion on Lower Lip MPR Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in